Can perhexiline be utilized without long-term toxicity? A clinical practice audit

H Phuong, BY Choi, CR Chong, B Raman… - Therapeutic drug …, 2016 - journals.lww.com
… with potentially interacting drugs (such as amiodarone, 25 … ) were not contraindications to
perhexiline therapy at entry. … details regarding concomitant CYP2D6 inhibitor therapy, this study …

Randomized controlled trial of perhexiline on regression of left ventricular hypertrophy in patients with symptomatic hypertrophic cardiomyopathy (RESOLVE-HCM trial …

R Ananthakrishna, SL Lee, J Foote, BC Sallustio… - American Heart …, 2021 - Elsevier
… • Current treatment with perhexiline or previous adverse reaction to perhexiline at therapeutic
… of recurrent hypoglycemia• Concomitant use of amiodarone, ranolazine or trimetazidine• …

[HTML][HTML] Drug-induced fatty liver disease: Pathogenesis and treatment

TO Kolaric, V Nincevic, L Kuna, K Duspara… - Journal of clinical and …, 2021 - ncbi.nlm.nih.gov
case report, the histopathology showed an absence of steatosis and phospholipidosis,
despite years of amiodarone … , such as amiodarone and perhexiline, drugs that can accelerate …

A Pharmacological Approach towards Myocardial Protection: New Perspectives in Acute and Chronic Cardiac Disease

CR Chong - 2017 - digital.library.adelaide.edu.au
… uptake of both perhexiline enantiomers in patients were slow… against the background of
concomitant therapy with other insulin-… compound, structurally similar to amiodarone) was also …

Drugs that affect cardiac metabolism: focus on perhexiline

CR Chong, B Sallustio, JD Horowitz - Cardiovascular drugs and therapy, 2016 - Springer
… for such therapies (for example because of concomitant severe systolic heart failure) and
by the … of the anti-ischaemic effects of perhexiline and amiodarone. However, excessive or …

Beta adrenergic antagonists and antianginal drugs

LM Stever, CJ Demitraszek, SA Murray… - Side effects of drugs …, 2021 - Elsevier
… to monitor patients receiving concomitant dabigatran and … , and C alleles were more common
in the case group. The TT + CT … that patients taking perhexiline or amiodarone should have …

Pharmacological treatment of hypertrophic cardiomyopathy: current practice and novel perspectives

E Ammirati, R Contri, R Coppini… - European journal of …, 2016 - Wiley Online Library
… to avoid concomitant therapy with other drugs associated … of nadolol with low-dose
amiodarone is well tolerated and … placebo-controlled trial, perhexiline has shown the capacity to …

Drug-induced peripheral neuropathies

KK Jain, KK Jain - Drug-induced neurological disorders, 2021 - Springer
… peripheral neuropathy when given concomitantly with cisplatin without interfering with …
perhexiline, like amiodarone, is a lipophilic drug capable of penetrating lysozymes. Perhexiline

[HTML][HTML] Detailed molecular mechanisms involved in drug-induced non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: An update

LG Di Pasqua, M Cagna, C Berardo, M Vairetti… - Biomedicines, 2022 - mdpi.com
… is concomitant with low hepatic energy production, the drugs … the antiarrhythmic drugs
amiodarone and perhexiline; drugs that … Moreover, in this case report a decrease in triglyceride …

Dronedarone, amiodarone and other antiarrhythmic drugs, and acute liver injuries: a case-referent study

L Grimaldi-Bensouda, H Wedemeyer, J Wiegand… - International Journal of …, 2018 - Elsevier
… Exposure to class III antiarrhythmic drugs was 4.0% in cases and 1.5% in controls, aOR =
3.6 (95% CI: 1.6–8.4). Associations with exposure to dronedarone and amiodarone were …